Ecuadorian-born, Miami-based designer Ximena Kavalekas uses python in every element of her handbag designs for the eponymous brand she founded in 2015. The bags are all Italian made, and Kavalekas started selling her first accessories to other moms at her children's school. Word of mouth around the bags grew, though, and the brand is now carried in places like Bergdorf Goodman and Net-a-Porter.